Daxxify vs. Botox

Deciphering the Best Anti-Aging Choice

What is Daxxify?

Daxxify represents the next wave in injectable treatments, targeting frown lines to provide a youthful look. This injectable neurotoxin, daxibotulinumtoxinA-lanm or Daxi, utilizes peptide exchange technology for accurate botulinum toxin delivery to nerve cells, offering temporary relief from moderate to severe lines. It blocks nerve signals that cause muscle contractions, thus softening expression lines. Daxxify stands out for not using human serum albumin or animal-derived components, which is common in traditional neuromodulators like Botox. This innovative peptide technology provides a safer, more natural option with prolonged effects.

Daxxify Before And Afters

What is Botox?

Botox employs a purified form of botulinum toxin to temporarily freeze facial muscles, reducing wrinkles from repetitive facial movements. It obstructs nerve signals to specific muscles, smoothing out dynamic wrinkles such as crow’s feet and forehead lines. Botox’s results are noticeable within days and can last for several months. Botox is renowned for effectively reducing wrinkles, particularly dynamic ones. It results in a visibly smoother and rejuvenated appearance.

Botox Before And Afters

Daxxify's Unique Selling Points vs. Botox

Botox's Established Reputation

BOTOX® Cosmetic (onabotulinumtoxinA) boasts the highest number of clinical studies in aesthetic medicine, with reported data across 528 publications, surpassing all similar products in the field. It was approved for therapeutic use in 1989, and approved by the FDA in 2002.

Longevity Daxxify/Botox Effects

Daxxify vs. Botox Cost Breakdown

In most practices, a Daxxify treatment costs more than a Botox cosmetic treatment. However, because Daxxify lasts a little longer than Botox and the other leading brands (Dysport, Xeomin, etc.), the price point could be lower.

For example, if a typical Botox client spends $1600 on Botox injections annually (four $400 treatments every three months), the typical Daxxify client will spend $1200 annually (two $600 treatments every six months). These prices are, of course, hypotheticals as pricing will vary by practice and location, but this gives you a general understanding as to why Daxxify is the more cost-effective option in the long run.
Update Nov. 2023: Daxxify just in the past few weeks has lowered its price to meet that of Botox. So, there is currently very little difference in price.

Daxxify Pricing vs. Botox Pricing

The specific price per unit is difficult to say, as this will depend on many factors. (Where in the country your provider is located, competitive local pricing, etc.). Typically, though, a single unit of Daxxify should cost less than a single unit of Botox, and you will receive double the units of Daxxify because the products are dosed differently. If you typically receive 25 units of Botox, you should expect to receive 50 units of Daxxify. We always recommend that our clients come in for a full-face consult and analysis before receiving treatment to provide the most accurate price quotes.

Eligibility: Botox and Daxxify

Injectable treatments such as Botox and Daxxify are generally well-received by most individuals. Typically, suitable candidates are those in overall good health without serious health issues, particularly those related to nerve or neuromuscular conditions. It is important to note that these injectable neuromodulators are not advisable for individuals who are pregnant or breastfeeding or for those with a known allergy to any components of the products.

Daxxify Clinical Trial Results

The authorization of Daxxify by the FDA was grounded in the outcomes of the Phase 3 clinical trial series (encompassing SAKURA 1, 2, and 3). These trials involved over 2,700 patients and around 4,200 treatment instances. Key findings from these pivotal trials include: 74% of participants showed an improvement of more than two grades in glabellar lines at the 4-week mark, as assessed by both investigators and patients. 88% exhibited an improvement of more than two grades at week 4, based on investigator assessments alone. 98% of participants had either no wrinkles or only mild wrinkle severity at week 4, as per investigator evaluations. The average duration of the treatment’s effect was six months. A number of patients experienced sustained results for up to nine months. Observable results were noted as early as one-day post-treatment, with the typical onset within two days.

Daxxify VS. Botox - Your Choice

The debate between Daxxify and Botox is about more than finding a universally superior option, but rather about identifying which product aligns best with your unique needs and expectations. Both treatments offer distinct advantages, and the optimal choice varies from person to person.

In the dynamic world of cosmetic treatments, personal preference, informed guidance, and a thorough understanding of your skin and expectations are crucial to selecting the right anti-aging solution. Whether it’s the innovative approach of Daxxify or the time-tested efficacy of Botox, the ultimate goal is achieving a refreshed, youthful appearance that boosts confidence and well-being.

The Role of Professional Guidance

Consulting with a dermatologist or a cosmetic skincare expert is essential. These professionals can provide:

Considerations for an Informed Decision on Daxxify and Botox

What are Neuromodulators?

In an era where aesthetic appeal holds significant value, many individuals are increasingly drawn to cosmetic procedures to preserve a youthful appearance. Among these, Botox and similar injectables have surged in popularity, becoming some of the top non-surgical choices, including Botox itself and dermal fillers.

As the natural aging process takes its course, our skin tends to lose both elasticity and volume, which leads to the development of fine lines and wrinkles. Neuromodulators are predominantly employed to diminish these signs of aging, particularly in the upper facial region. They are commonly used to treat areas like:

How Neuromodulators Like Daxxify and Botox Function

Neuromodulators such as Botox and Daxxify act directly on the nerves in the targeted area. They are derived from Clostridium botulinum, a bacterium known for producing a neurotoxic protein. By curbing the production of acetylcholine, these neuromodulators disrupt the nerve signals that lead to muscle contractions, resulting in a relaxation of the muscles. This relaxation contributes to a smoother, more line-free appearance of the skin.

Daxxify’s Mechanism of Action

Daxxify (daxibotulinumtoxinA-lanm) acts by disrupting cholinergic transmission at neuromuscular junctions, primarily through inhibiting acetylcholine release. Once Daxxify is administered into skeletal muscle, it is absorbed by the nerve endings. Inside the nerve cells, it targets and breaks down SNAP25, an essential protein required for the merging of synaptic vesicles and the subsequent release of acetylcholine, resulting in a dose-dependent reduction in muscle activity. The recovery process is slow and involves the breakdown of the neurotoxin’s light chain within the neurons, supplemented by the growth of new nerve fibers. This leads to muscle reinnervation, gradually diminishing the pharmacological impact of Daxxify.

Recap: Botox Vs. Daxxify


  • More prolonged Effects: Lasts 6-9 months, outperforming Botox’s 3-4 months.
  • Innovative Tech: Uses peptide exchange technology for a safer, more natural approach.
  • Skin Benefits: Patients report improved skin appearance from the peptide technology.


  • Proven Efficacy: Trusted for effectively reducing dynamic wrinkles.
  • Fast Results: Offers immediate appearance improvement.
  • Versatile Use: Beyond cosmetics, it’s used for various medical conditions.